Development and challenges in the treatment of advanced gallbladder cancer (Review)

Area of Science:

• Oncology
• Gastroenterology

Background:

• Gallbladder cancer (GBC) is a lethal biliary tract malignancy.
• Many patients present with advanced disease, restricting treatment options.
• Current 5-year survival rates for GBC remain low, highlighting an unmet clinical need.

Purpose of the Study:

• To systematically review and analyze recent treatment trends in advanced GBC.
• To identify persistent challenges in managing advanced gallbladder cancer.
• To summarize the latest research developments for GBC therapy.

Main Methods:

• Systematic literature review using PubMed and Web of Science.
• Analysis focused on publications from the past decade.
• Synthesis of data on treatment modalities and research progress.

Main Results:

• Identified various therapeutic strategies for advanced GBC, including local therapy, chemoradiotherapy, immunotherapy, and targeted therapy.
• Highlighted ongoing challenges despite treatment advancements.
• Summarized recent research innovations and their potential impact.

Conclusions:

• Advanced GBC management requires multifaceted approaches.
• Continued research is crucial to overcome therapeutic limitations and improve survival.
• The review provides insights into current and future directions for GBC treatment.