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Engineering

Senescence-resistant human mesenchymal progenitor cells counter aging in primates

Jinghui Lei¹, Zijuan Xin², Ning Liu³

¹Advanced Innovation Center for Human Brain Protection, National Clinical Research Center for Geriatric Disorders, Aging Translational Medicine Center, Beijing Municipal Geriatric Medical Research Center, Beijing Key Laboratory of Environment and Aging, Xuanwu Hospital Capital Medical University, Beijing 100053, China.

Cell|June 14, 2025

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Materials Engineering

Functional Materials

Senescence-resistant Human Mesenchymal Progenitor Cells Counter Aging In Primates

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View abstract on PubMed

Summary

Genetically modified mesenchymal progenitor cells (SRCs) were developed to resist aging. In aged macaques, SRC treatment reduced aging indicators, improved cognition, and slowed reproductive decline, showing potential for regenerative medicine.

Area of Science:

Gerontology and Regenerative Medicine
Cellular and Molecular Biology

Background:

Aging involves stem cell dysfunction, limiting regenerative potential.
Current strategies to counteract aging lack defined efficacy.
Mesenchymal progenitor cells offer therapeutic promise but require enhancement.

Purpose of the Study:

To develop senescence-resistant progenitor cells (SRCs) for enhanced resilience.
To evaluate the efficacy of SRCs in mitigating age-related decline in aged primates.
To investigate the potential of SRC-derived exosomes in combating cellular senescence.

Main Methods:

Genetic modification of human mesenchymal progenitor cells to create senescence resistance.
Intravenous administration of SRCs in a 44-week aged macaque study.
Assessment of systemic aging indicators, cognitive function, and reproductive health.

Main Results:

Systemic reduction in cellular senescence, chronic inflammation, and tissue degeneration.
Significant enhancement of brain architecture and cognitive performance.
Alleviation of age-related reproductive system decline without adverse effects.
Evidence of SRC-derived exosomes contributing to senescence mitigation.

Conclusions:

Genetically modified human mesenchymal progenitors can effectively slow primate aging.
SRCs demonstrate therapeutic potential in regenerative medicine for age-related diseases.
Exosomes play a role in the anti-aging effects of SRCs.

Keywords:

FOXO3 aging biomarker brain gene editing intervention rejuvenation reproductive system senescence stem cell

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Senescence-resistant human mesenchymal progenitor cells counter aging in primates | JoVE Visualize