Unveiling the antioxidant potential of new modified hyaluronan derivatives: Design, synthesis, characterization, antioxidant evaluation, and in-silico ADMET with molecular docking simulation
1Centre of Experimental Medicine of Slovak Academy of Sciences, Dúbravská cesta 9, 84104 Bratislava, Slovakia; Centre of Scientific Excellence-Group of Advanced Materials and Nanotechnology, Chemistry of Natural and Microbial Products Department, National Research Center, El Behouth Street, 12622 Cairo, Egypt.
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Summary
Novel aromatic derivatives of hyaluronan (HA) show potential for advanced wound dressings. These biocompatible materials possess antioxidant and anti-inflammatory properties, aiding chronic wound healing and fighting bacteria.
Area of Science:
- Biomaterials Science
- Polymer Chemistry
- Dermatology
Background:
- Hyaluronan (HA), a key extracellular matrix glycosaminoglycan, influences tissue structure and biological functions.
- Its network-forming ability and negative charge are vital for biochemical activities.
- Chemical modification of HA yields novel biocompatible and degradable materials.
Purpose of the Study:
- To synthesize and characterize novel aromatic derivatives of hyaluronan.
- To evaluate the antioxidant and anti-inflammatory potential of these derivatives.
- To explore their therapeutic applications in wound healing.
Main Methods:
- Synthesis of HA derivatives using 4-(Dimethylamino)benzaldehyde and 2',4',6'-Trihydroxyacetophenone.
- Characterization via Fourier transform infrared spectroscopy, electronic spectrum analysis, thermal gravimetric analysis, and differential scanning calorimetry.
- Assessment of free-radical scavenging activity using ABTS and DPPH assays, alongside molecular docking and pharmacokinetic studies.
Main Results:
- Successful formulation of novel aromatic hyaluronan derivatives.
- Demonstrated significant free-radical scavenging and antioxidant activities.
- Molecular docking and pharmacokinetic analyses elucidated antioxidant mechanisms and therapeutic potential.
Conclusions:
- The novel HA derivatives exhibit promising anti-inflammatory and antioxidant properties.
- These derivatives are suitable for developing specialized wound dressings.
- The developed wound dressings can combat pathogenic bacteria and facilitate chronic skin wound treatment.